Should You Pursue Your Manuscript--Or Set It Aside--After Multiple Rejections (AKA Who Are You Writing This For?)

One of my students from Canada recently contacted me after the third small press rejected her memoir manuscript.  The publisher was seriously interested but, after some thought. changed his mind.  The press offered detailed feedback--in itself an encouragement--which she appreciated.

But it's her third rejection after serious interest, and she's losing h…